Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms
AssigneeThe Trustees of Columbia University in the City of New York
InventorsRebecca Anne Brachman, Christine Ann Denny, René Hen
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Abstract
Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are methods for inducing and/or enhancing stress resilience in a subject. In certain embodiments, an effective amount, of an antagonist of the glutamate N-methyl-D-aspartate (NMDA) receptor, such as ketamine, or a pharmaceutically acceptable salt or derivative thereof, is administered to a subject prior to a stressor.
Claims9
A method for preventing or delaying a stress-induced affective disorder or stress-induced psychopathology in a subject, the method consisting of administering, once or twice, an effective amount of a pharmaceutic composition consisting of ketamine to the subject, wherein the method consists of administering the pharmaceutic composition to the subject 1 week prior to the stressor.
Dependencies are inferred from the claim text.