Inhibition of mammalian target of rapamycin
AssigneesBoard of Regents, The University of Texas System, Southwest Research Institute
InventorsZelton Dave Sharp, John R. Strong, Veronica Galvan, Salvatore Oddo, Herbert G. Wheeler
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Abstract
Disclosed are microcapsules that include an inhibitor of the mammalian target of rapamycin (mTOR) within the microcapsules, and pharmaceutical compositions and kits that include the microcapsules. Also disclosed are methods for treating or preventing an age-related disease, condition, or disorder in a subject that involve administering to a subject a pharmaceutically effective amount of microcapsules that includes an inhibitor of mTOR within the microcapsules.
Claims7
A microcapsule consisting essentially of a core component comprising at least 5% by weight of an inhibitor of mammalian target of rapamycin (mTOR) which is rapamycin or a rapamycin analog, wherein said core component is microencapsulated and encased in a coating that includes a methyl methacrylate-methacrylic acid copolymer.
A kit comprising a first sealed container comprising a microcapsule, wherein the microcapsule is comprised of a core component comprising at least 5% by weight of an inhibitor of mammalian target of rapamycin (mTOR) which is rapamycin or a rapamycin analog, wherein said core component is microencapsulated and encased in a coating that includes a methyl methacrylate-methacrylic acid copolymer.
Dependencies are inferred from the claim text.