Gel formulation for treating diabetic foot ulcer infections

A gel formulation for treating diabetic foot ulcer infections, said formulation comprising:

• antibiotic loaded aquasomes having a diameter in the range of 80 nm to 120 nm as measured by a zeta sizer instrument;
• a gelling agent;
• a preservative;
• and
• a fluid medium,
• wherein said antibiotic loaded aquasomes includes antibiotic loaded on a polyhydroxy oligomer coated calcium phosphate,
• wherein said polyhydroxy oligomer is selected from the group consisting of lactose, trehalose, and cellobiose,
• wherein said antibiotic loaded aquasomes include a calcium phosphate core having a particle diameter in the range of 45 nm to 55 nm as measured by a zeta sizer instrument, coated with polyhydroxy oligomer thereon followed by coating of an antibiotic on said aquasomes,
• wherein said aquasomes are in an amount in the range of 15 wt % to 20 wt % of the total weight of said formulation;
• said gelling agent is in an amount in the range of 70 wt % to 90 wt % of the total weight of said formulation;
• said preservative is in an amount in the range of 0.05 wt % to 0.25 wt % of the total weight of said formulation;
• and said fluid medium is in an amount in the range of 1 wt % to 4 wt % of the total weight of said formulation,
• wherein the pH of said gel formulation is in the range of 6.0 to 7.0, and
• wherein the said the gel formulation is stable over the period of 6 months.