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AssigneeSlayback Pharma LLC
InventorsRahul Dhulaji Bhise, Ajay Kumar Singh, Mahadeo Vasant Mahadik, Ashish Anilrao Dubewar, Molugu Prashanth Reddy
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The present invention provides stable, ready-to-use injectable pharmaceutical compositions, comprising the combination of neostigmine, glycopyrrolate, a stabilizing amount of one or more aminopolycarboxylic acids, and a pharmaceutically acceptable liquid vehicle. Other aspects of the invention relate to methods for making such compositions and methods of using such compositions for reversing the effects of non-depolarizing neuromuscular blocking agents. Preferably, the composition comprises neostigmine methylsulfate, glycopyrronium bromide, ethylenediaminetetraacetic acid (EDTA) and a pharmaceutically acceptable liquid vehicle, and is provided in a pre-filled, ready-to-use sealed container, such as a pre-filled syringe, suitable for intravenous administration.
A stable ready-to-use injectable pharmaceutical composition for reversing the effects of non-depolarizing neuromuscular blocking agents in a patient in need thereof, comprising (i) about 1 mg/mL of neostigmine or a pharmaceutically acceptable salt, solvate or hydrate thereof, (ii) about 0.2 mg/mL of glycopyrrolate or a pharmaceutically acceptable salt, solvate or hydrate thereof, (iii) a pharmaceutically acceptable liquid vehicle, (iv) a tonicity modifier;
A stable ready-to-use injectable pharmaceutical composition comprising (i) about 1 mg/mL of neostigmine methylsulfate, (ii) about 0.2 mg/mL of glycopyrronium bromide, (iii) a pharmaceutically acceptable liquid vehicle;
A stable ready-to-use injectable pharmaceutical composition consisting of (i) about 1 mg/mL of neostigmine methylsulfate, (ii) about 0.2 mg/mL of glycopyrronium bromide, (iii) a pharmaceutically acceptable liquid vehicle;
Dependencies are inferred from the claim text.