Expandable drug delivery devices and methods of use

A drug delivery device configured to be at least partially implanted in an eye, the device comprising:

• a retention structure positioned near a proximal end region of the device;
• a porous drug release element positioned in fluid communication with an outlet of the device;
• an elongated core element having a longitudinal axis;
• and
• a reservoir formed of a non-compliant material positioned around the elongated core element, the reservoir having a volume configured to contain one or more therapeutic agents and to be in fluid communication with the outlet through the porous drug release element,
• wherein the device is configured to be at least partially inserted into the eye, and
• wherein the reservoir is configured to enlarge in a non-distensible manner from an insertion configuration having a first three-dimensional shape to a deployed configuration having a second three-dimensional shape, such that the second three-dimensional shape is eccentrically positioned relative to the longitudinal axis of the elongated core element.