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US 11,098,114 B2Granted
Ovine derived human TNFα polyclonal antibody composition for oral administration
AssigneeMicroPharm Limited
InventorsJohn Landon, Ruth Elizabeth Coxon
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Abstract
The present invention is directed to an antibody composition for oral administration comprising intact blood-derived polyclonal antibodies that bind to a human tumour necrosis factor α (TNFα), and means for protecting the antibodies during gastrointestinal transit, as well as methods for manufacturing, kits, and therapeutic uses of the same.
Claims13
An antibody composition for oral administration comprising:
- a. intact blood-derived polyclonal antibodies that bind to a human tumour necrosis factor a (TNFα);
- and
- b. a protease inhibitor and/or an antacid,
- wherein the intact blood-derived polyclonal antibodies are derived from serum or plasma of an ovine mammal administered TNFα or a fragment thereof.
1 more element
A method for manufacturing an antibody composition for oral administration, said method comprising:
- a. obtaining a blood sample from an ovine mammal that has been administered an immunogen comprising human tumour necrosis factor a (TNFα) or a fragment thereof, thereby providing a sample comprising intact blood-derived polyclonal antibodies that bind to TNFα;
- b. admixing the intact blood-derived polyclonal antibodies that bind to human TNFα with a protease inhibitor and/or an antacid.
Dependencies are inferred from the claim text.