US 11,079,613 B2Granted

Contact lens drug depot

AssigneeEyeYon Medical Ltd.

InventorsOfer Daphna, Brian Levy, Nahum Ferera

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Abstract

A method includes placing a contact lens over a cornea of an eye. The contact lens includes a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc on the posterior portion, and one or more apertures formed in the groove. A drug substance is placed over the anterior portion of the contact lens. The groove is in contact with the cornea and is a depot for the drug substance. The groove is in fluid connection with the anterior portion of the lens via the one or more apertures. The drug substance moves in an undiluted manner to the groove and the contact lens holds the drug substance in contact with the cornea, unaffected by blinking or tear exchange, facilitating enhanced bioavailability to the cornea of the drug substance.

Claims9

Dependent claims

A method comprising:

placing a contact lens over a cornea of an eye, said contact lens having a posterior portion in contact with the cornea and an anterior portion facing an external environment which is external to the eye, and wherein said contact lens comprises a central convex disc, a peripheral curved portion that extends radially from said disc, an annular groove formed in said disc on said posterior portion, and one or more apertures formed in said groove;
and
placing a drug substance over the anterior portion of said contact lens, wherein said groove on said posterior portion that is in contact with the cornea is a depot for the drug substance, said groove being in fluid connection with said anterior portion via said one or more apertures, such that the drug substance moves to said groove which is in contact with the cornea and said contact lens holds the drug substance in contact with the cornea, without detrimental effects from blinking or tear exchange, facilitating enhanced bioavailability to the cornea of the drug substance.

Dependencies are inferred from the claim text.

Facts

Application: 15/947,826Filed 8 Apr 2018 · continuation in part
Priority: 5 Mar 2013
Published: US 2018/0224670 A19 Aug 2018
Granted: 3 Aug 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

G02C 7/04
Lenses; Lens systems ; Methods of designing lenses: contact lenses for the eyes
A61F 9/0017
Introducing ophthalmic products into the ocular cavity or retaining products therein: implantable in, or in contact with, the eye, e.g. ocular inserts
G02C 7/047
Contact lenses for the eyes: contact lens fitting; Contact lenses for orthokeratology; Contact lenses for specially shaped corneae
G02C 7/049
Contact lenses for the eyes: contact lenses having special fitting or structural features achieved by special materials or material structures

Family

Application13/785,157Parent of this continuation · filed 5 Mar 2013
Application14/814,521Parent of this continuation-in-part · filed 31 Jul 2015
Application15/422,599Parent of this continuation-in-part · filed 2 Feb 2017
US 2018/0224670 A1Pre-grant publication · published 9 Aug 2018
US 9,927,632 B2Parent of this continuation-in-part
US 9,097,915 B2Parent of this continuation
Application14/814,521Parent of this continuation
US 2014/0253869 A1Published application
US 2017/0031180 A1Published application
US 2017/0143540 A1Published application
US 11,079,613 B2This patent

From the US filing history. Foreign family members aren’t listed.

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