Method and apparatus for determining a patient's filtration rate
AssigneeFresenius Medical Care Deutschland GmbH
InventorsPaul Chamney, Peter Wabel
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Abstract
A method and an apparatus for determining or approximating a patient's glomerular filtration rate or a patient's creatinine clearance are disclosed. The method comprises the following steps: determining a serum creatinine concentration of the patient, determining a lean tissue mass of the patient, and determining the glomerular filtration rate of the patient or the creatinine clearance of the patient based on the serum creatinine concentration of the patient and the lean tissue mass of the patient.
Claims18
Method for determining or approximating a patient's glomerular filtration rate or a patient's creatinine clearance in a patient undergoing intermittently a renal replacement treatment, the method comprising the steps of:
- determining a serum creatinine concentration of the patient,
- determining a lean tissue mass of the patient,
- determining the glomerular filtration rate of the patient or the creatinine clearance of the patient without using age or gender of the patient and based on the serum creatinine concentration of the patient and the lean tissue mass of the patient,
- determining which of chronic kidney disease (CKD) stages 1-5 the patient is in based on the determined glomerular filtration rate or creatinine clearance, and
- determining a criterion for applying a renal replacement therapy to the patient based on the determined glomerular filtration rate or creatinine clearance of the patient,
- wherein the step of determining the serum creatinine concentration includes determining a first serum creatinine concentration at a first time between treatment sessions and determining a second serum creatinine concentration at a second time between treatment sessions and wherein the step of determining the patient's glomerular filtration rate or creatinine clearance is based on the first creatinine concentration and on the second creatinine concentration.
Apparatus for determining or approximating a patient's glomerular filtration rate or a patient's creatinine clearance, the apparatus comprising:
- a first receiver configured to receive a serum creatinine concentration of the patient, a second receiver configured to include or connect to a measuring unit for measuring a lean tissue mass of the patient, and a central processing unit configured to determine (i) the glomerular filtration rate Qgfr of the patient by applying the formula
- Q
- gfr
- =
- α
- ltm
- ·
- M
- LT
- m
- β
- ts
- ·
- [
- Cr
- ]
- s
- wherein MLTm is the lean tissue mass of the patient, [Cr]s is the serum creatinine concentration, and αltm and βts are proportionality constants, or (ii) the creatinine clearance of the patient by applying the formula
- K
- Cr_WB
- =
- α
- ltm
- ·
- M
- LT_m
- [
- Cr
- ]
- s
- wherein MLT_m is the lean tissue mass of the patient, [Cr]s is the serum creatinine concentration and αltm is a proportionality constant, without using age or gender of the patient.
Dependencies are inferred from the claim text.