Detection of angiopoietin-2 and thrombospondin-2 in connection with diagnosing acute heart failure
AssigneesVanderbilt University, Beth Israel Deaconess Medical Center, Inc.
InventorsThomas J. Wang, Deepak K. Gupta, Quinn S. Wells, Robert E. Gerszten
Life of this patent
Estimating the term…
Abstract
Methods for detecting angiopoietin-2 (Angpt-2) and/or thrombospondin-2 (Tsp-2) in a sample involve obtaining or having obtained a blood or plasma sample from a subject; and detecting Angpt-2 and Tsp-2 in the sample. Detecting can involve performing an assay to determine whether the sample includes Angpt-2 and/or Tsp-2 or elevated levels of Angpt-2 and/or Tsp-2. Elevated levels are indicative of acute heart failure.
Claims14
A method for treating a subject, comprising:
- (a) determining whether there is angiopoietin-2 (Angpt-2) and/or thrombospondin-2 (Tsp-2) in a blood or plasma sample from the subject by:
- (i) obtaining or having obtained the blood or plasma sample from the subject;
- (ii) performing or having performed an assay to determine whether the sample includes an elevated level of Angpt-2 and/or Tsp-2, wherein it is determined that there is elevated Angpt-2 in the sample when the level of Angpt-2 is above about 220 pg/ml and that there is elevated Tsp-2 in the sample when the level of Tsp-2 is above about 30 ng/ml;
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- (b) if there is an elevated level of Angpt-2 and/or Tsp-2 in the sample, then administering treatment for acute heart failure comprising administering diuretics to the subject.
A method of diagnosing and treating acute heart failure in a subject, said method comprising:
- (a) obtaining or having obtained a blood or plasma sample from the subject to detect levels in the sample of one or both of angiopoietin-2 (Angpt-2) and thrombospondin-2 (Tsp-2);
- (c) diagnosing the subject with acute heart failure when there is an elevated level of Angpt-2 and/or Tsp-2 in the sample, wherein it is determined that there is elevated Angpt-2 in the sample when the level of Angpt-2 is above about 220 pg/ml and that there is elevated Tsp-2 in the sample when the level of Tsp-2 is above about 30 ng/ml;
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- (d) administering treatment for acute heart failure comprising administering diuretics to the diagnosed subject.
A method of detecting a combination of angiopoietin-2 (Angpt-2) and thrombospondin-2 (Tsp-2) in a sample from a subject, comprising:
- (a) obtaining or having obtained a blood or plasma sample from the subject;
- (b) detecting or having detected Angpt-2 and Tsp-2 in the sample;
- (c) diagnosing the subject with acute heart failure when there is an elevated level of Angpt-2 and/or Tsp-2 in the sample as compared to a non-heart failure control;
- and
- d) administering treatment for acute heart failure to the subject, said treatment comprising administering diuretics to the subject.
Dependencies are inferred from the claim text.