Monoclonal antibody against FZD10 and use thereof
AssigneeOncotherapy Science, Inc.
InventorsYosuke Harada, Tatsuki Yokoseki, Yusuke Nakamura
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Abstract
The present invention relates to monoclonal antibodies against FZD10. Furthermore, the present invention provides methods for diagnosing FZD10-related diseases using such an antibody, methods for detecting a FZD10 protein, methods for determining drug efficacy after treatment with FZD10 inhibitors, and methods of screening for subjects in whom treatment with FZD10 inhibitors is highly effective, and provides diagnostic reagents containing such an antibody.
Claims16
An antibody or antigen-binding fragment thereof capable of binding to a FZD10 protein or a partial peptide thereof, which comprises both of:
- a heavy chain variable region comprising
- CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1,
- CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2, and
- CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3;
- and
- a light chain variable region comprising
- CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4,
- CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and
- CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.