Sampling apparatus for determining the amount and uniformity of a delivered dose of drug and related methods

An apparatus for collecting a sample dose from a drug delivery device, wherein the apparatus comprises

• a) a collection assembly that comprises i) a collection container that comprises a hollow cylinder having an inner surface and an outer surface, and a first opening at a proximal end and a second opening at a distal end of the hollow cylinder, wherein the second opening is configured to allow the collection container to connect to a system configured to apply negative pressure through the second opening;
• ii) a closure assembly that comprises a resealable inlet baffle operatively connected to the proximal end of the collection container and comprises a central opening which receives a mouthpiece of the drug delivery device and forms a seal between the collection container and the mouthpiece, and wherein the central opening of the resealable inlet baffle is configured to receive a removable plunger such that the removable plunger passes through the resealable inlet baffle into the collection container and contacts the inner surface of the collection container;
• and iii) a resealable nozzle operatively connected to the second opening;
• and
• b) a removable plunger configured to pass through the resealable inlet baffle into the collection container and contact the inner surface of the collection container.