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US 11,078,489 B2Granted
Methods and compositions for backscattering interferometry
AssigneeBase Pair Biotechnologies, Inc.
InventorsGeorge W. Jackson, Darryl Bornhop
Life of this patent
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Abstract
The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.
Claims7
A non-labeled molecular beacon comprising:
- a hairpin aptamer having a non-self-hybridizing loop region and self-hybridizing stem region, said hairpin aptamer comprising a non-naturally occurring sequence comprising the sequence of SEQ ID No. 1;
- wherein said self-hybridizing stem region dehybridizes upon binding of said hairpin aptamer to a target molecule to elicit a conformational change in said hairpin aptamer.
Dependencies are inferred from the claim text.