Multimeric oligonucleotides having decreased kidney clearance
AssigneeMpeg La, LLC
InventorsJonathan Miles Brown, Kristin K. H. Neuman, Hans-Peter Vornlocher, Philipp Hadwiger
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Abstract
The present invention relates to methods of administering to a subject multimeric oligonucleotides having monomeric subunits joined by linkers. The multimeric oligonucleotides have a molecular weight of at least about 45 kD and other characteristics, such that their clearance due to glomerular filtration is reduced. The present invention also relates to such multimeric oligonucleotides and methods of synthesizing such multimeric oligonucleotides.
Claims44
A method of administering a multimeric oligonucleotide to a subject in need thereof, the method comprising administering an effective amount of the multimeric oligonucleotide to the subject, the multimeric oligonucleotide comprising subunits , wherein:
- each of the subunits is independently a single or double stranded oligonucleotide, and each of the subunits is joined to another subunit by a covalent linker ●;
- the multimeric oligonucleotide has a molecular weight and/or size configured to decrease its clearance due to glomerular filtration;
- and
- the molecular weight of the multimeric oligonucleotide is at least about 45 kD;
- and the decreased clearance due to glomerular filtration results in increased in vivo circulation half-life of the multimeric oligonucleotide.
Dependencies are inferred from the claim text.