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US 11,078,295 B2Granted
Use of semaphorin-4D inhibitory molecules with an immune modulating therapy to inhibit tumor growth and metastases
AssigneeVaccinex, Inc.
InventorsElizabeth Evans, Ernest S. Smith, Maurice Zauderer
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Abstract
Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of Plexin-B1-expressing cancer cells in a subject, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) in combination with an effective amount of at least one other immune modulating therapy.
Claims20
A method for inhibiting, delaying, or reducing solid tumor growth in a subject with cancer, comprising
- (a) determining the levels of B cells and/or T cells in a subject with cancer;
- and
- (b) administering to the subject an effective amount of an isolated antibody or antigen-binding fragment thereof that specifically binds to semaphorin-4D (SEMA4D) if the levels of B cells and/or T cells per microliter of blood in the subject are at least 1.5 times the mean number of B cells and/or T cells in circulation in other cancer patients with solid tumors, thereby treating the subject with cancer,
- wherein the antibody or antigen-binding fragment thereof that specifically binds to SEMA4D comprises a variable heavy chain (VH) comprising VHCDRs 1-3 comprising SEQ ID NOs 6, 7, and 8, respectively, and a variable light chain (VL) comprising VLCDRs 1-3 comprising SEQ ID NOs 14, 15, and 16, respectively.
1 more element
Dependencies are inferred from the claim text.