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AssigneeAblynx N.V.
InventorsEls Anna Alice Beirnaert, Sigrid Cornelis, Hendricus Renerus Jacobus Mattheus Hoogenboom
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The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
A method for inhibiting and/or preventing binding of RANK-L to RANK, wherein the method comprises at least the step of contacting RANK-L with at least one polypeptide that specifically binds to RANK-L, or with a composition comprising at least one polypeptide that specifically binds to RANK-L, wherein the at least one polypeptide comprises or essentially consists of 4 framework regions (FR1 to FR4 respectively) and 3 complementary determining regions (CDR1 to CDR3 respectively), in which:
A polypeptide that specifically binds to RANK-L, wherein the polypeptide comprises or essentially consists of 4 framework regions (FR1 to FR4 respectively) and 3 complementary determining regions (CDR1 to CDR3 respectively), in which:
Dependencies are inferred from the claim text.