Binding agonist for treatment of neurological and other disorders

A method of treating sensorineural hearing loss in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a TrkB agonist antibody comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises complementarity determining region (CDR) H1, CDRH2, and CDRH3 of SEQ ID NO:

• 6, SEQ ID NO:
• 7, and SEQ ID NO:
• 8, respectively, and the light chain variable region comprises CDRL1, CDRL2, and CDRL3 of SEQ ID NO:
• 3, SEQ ID NO:
• 4, and SEQ ID NO:
• 5, respectively.