Treatment of pediatric brain tumors with targeting of CD47 pathway

A method of treating a metastatic pediatric brain tumor in an individual, the method comprising:

• administering to the individual with a pediatric brain tumor by direct central nervous system delivery with an implantable continuous delivery device implanted in the ventricles of the brain, anti-CD47 antibody hu5F9-G4 at a dose of from 10 mg/kg to 50 mg/kg effective to increase depletion of pediatric brain tumor cells and reduce metastasis to the meninges and/or spine.

A method of treating metastasis to the meninges and/or spine for a pediatric medulloblastoma in an individual, the method comprising:

• administering by intraventricular CNS administration to the individual with a metastatic pediatric medulloblastoma anti-CD47 antibody hu5F9-G4 at a dose of from 10 mg/kg to 50 mg/kg effective to increase depletion of medulloblastoma cells metastasized to the meninges and/or spine;
• and
• administering systemically anti-CD47 antibody hu5F9-G4 at a dose of from 10 mg/kg to 50 mg/kg effective to decrease volume of the primary tumor.