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US 11,078,271 B2Granted
Anti-claudin-2 monoclonal antibody
AssigneeOsaka University
InventorsMasuo Kondoh, Kiyohito Yagi, Akihiro Watari, Masayoshi Fukasawa, Minoru Tada, Jun Kunisawa
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Abstract
An object of the present invention is to provide a monoclonal antibody that recognizes an extracellular region of Claudin-2. A monoclonal antibody that specifically binds to an extracellular region of Claudin-2.
Claims16
A monoclonal antibody that specifically binds to an extracellular region of Claudin-2, the monoclonal antibody comprising:
- the heavy-chain variable region comprising the amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO:
- 13 and the light-chain variable region comprising the amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO:
- 15;
- and wherein the heavy-chain variable region comprising:
- heavy-chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, heavy-chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 3, and heavy-chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 5;
- and wherein the light-chain variable region comprising:
- light-chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 7, light-chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 9, and light-chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 11.
10 more elements
A monoclonal antibody that specifically binds to an extracellular region of Claudin-2, the monoclonal antibody comprising:
- the heavy-chain variable region comprising the amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO:
- 14 and the light-chain variable region comprising the amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO:
- 16;
- and wherein the heavy-chain variable region comprising:
- heavy-chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 2, heavy-chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 4, and heavy-chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6;
- and wherein the light-chain variable region comprising:
- light-chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 8, light-chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 10, and light-chain CDR3 comprising the amino acid of SEQ ID NO:
- 12.
10 more elements
Dependencies are inferred from the claim text.