IL-11 antibodies
AssigneesSingapore Health Services Pte Ltd, National University of Singapore
InventorsStuart Alexander Cook, Sebastian Schaefer
Life of this patent
Estimating the term…
Abstract
IL-11 antibodies are disclosed. Also disclosed are compositions comprising the IL-11 antibodies, and methods using the IL-11 antibodies.
Claims11
An antibody or antigen binding fragment, which is capable of binding to IL-11, comprising a light chain variable region sequence and a heavy chain variable region sequence, wherein:
- the light chain variable region sequence comprises the following CDRs:
- i)
- LC-CDR1:
- (SEQ ID NO:
- 107)
- SSDVGGYNY;
- ii)
- LC-CDR2:
- (SEQ ID NO:
- 291)
- DVN;
- and
- iii)
- LC-CDR3:
- (SEQ ID NO:
- 336)
- CSYAGRYTWM;
- or a variant comprising 1 amino acid substitution in the sequence CSYAGRYTWM (SEQ ID NO:
- 336);
- and
- the heavy chain variable region sequence comprises the following CDRs:
- i)
- HC-CDR1:
- (SEQ ID NO:
- 186)
- GFTFSSYG
- ii)
- HC-CDR2:
- (SEQ ID NO:
- 184)
- ISYDGSNK;
- and
- iii)
- HC-CDR3:
- (SEQ ID NO:
- 187)
- AKIGATDPLDY.
A method of treating fibrosis or a disease/disorder characterised by fibrosis, comprising administering an antibody or antigen binding fragment to a subject suffering from fibrosis or a disease/disorder characterised by fibrosis, wherein the antibody or antigen binding fragment is capable of binding to IL-11, and comprises a light chain variable region sequence and a heavy chain variable region sequence, wherein:
- the light chain variable region sequence comprises the following CDRs:
- i)
- LC-CDR1:
- (SEQ ID NO:
- 107)
- SSDVGGYNY;
- ii)
- LC-CDR2:
- (SEQ ID NO:
- 291)
- DVN;
- and
- iii)
- LC-CDR3:
- (SEQ ID NO:
- 336)
- CSYAGRYTWM;
- or a variant comprising 1 amino acid substitution in the sequence CSYAGRYTWM (SEQ ID NO:
- 336);
- and
- the heavy chain variable region sequence comprises the following CDRs:
- i)
- HC-CDR1:
- (SEQ ID NO:
- 186)
- GFTFSSYG
- ii)
- HC-CDR2:
- (SEQ ID NO:
- 184)
- ISYDGSNK;
- and
- iii)
- HC-CDR3:
- (SEQ ID NO:
- 187)
- AKIGATDPLDY.
Dependencies are inferred from the claim text.