High viscosity macromolecular compositions for treating ocular conditions

A method for treating a posterior ocular condition, the method comprising:

• administering into the vitreous of an eye of a mammal suffering from an ocular condition a composition consisting of;
• a therapeutically effective amount of a macromolecular anti-angiogenic component (MAAC), wherein the MAAC is selected from a VEGF antibody comprising bevacizumab, a VEGF antibody fragment comprising ranibizumab, a VEGF antibody mimic comprising CT-322, C7S100, or C7C100, and combinations thereof;
• a viscosity inducing component in an amount effective to increase the viscosity of the composition to a viscosity at about 25° C. of at least 10 cps at a shear rate of about 0.1/second, wherein said viscosity inducing component is injectable into the vitreous of a mammalian eye without permanently diminishing visual acuity,
• sodium chloride,
• dibasic sodium phosphate heptahydrate, monobasic sodium phosphate monohydrate, and
• water;
• wherein the posterior ocular condition is selected from macular edema, macular degeneration, diabetic retinopathy, and combinations thereof;
• and
• wherein the administering is by subconjunctival, suprachoroidal, intravitreal or combination thereof.