Anti-N3pGlu amyloid beta peptide antibodies and uses thereof
AssigneeEli Lilly and Company
InventorsRonald Bradley Demattos, Jirong Lu, Ying Tang
Life of this patent
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Abstract
Antibodies to human N3pGlu Aβ, compositions comprising such N3pGlu Aβ antibodies, and methods of using such N3pGlu Aβ antibodies for the treatment of a disease characterized by deposition of Aβ including clinical or pre-clinical Alzheimer's disease, Down's syndrome, and clinical or pre-clinical cerebral amyloid angiopathy.
Claims9
A DNA molecule comprising a polynucleotide that encodes an antibody heavy chain comprising SEQ ID NO:12.
A DNA molecule comprising a polynucleotide that encodes an antibody light chain comprising SEQ ID NO:13.
A DNA molecule comprising a polynucleotide sequence that encodes an antibody heavy chain comprising SEQ ID NO:
- 12 and a polynucleotide sequence that encodes an antibody light chain comprising SEQ ID NO:
- 13.
A mammalian cell transformed with a DNA molecule comprising:
- a polynucleotide that encodes an antibody heavy chain comprising SEQ ID NO:
- 12 and/or a polynucleotide that encodes an antibody light chain comprising SEQ ID NO:
- 13.
A process for producing an antibody comprising two heavy chains and two light chains, wherein each heavy chain comprises SEQ ID NO:
- 12, and each light chain comprises SEQ ID NO:
- 13, and wherein the process comprises:
- a) expressing the antibody under suitable conditions in a mammalian cell, and b) recovering the expressed antibody.
Dependencies are inferred from the claim text.