Antibodies to endoplasmin and their use

An isolated chimeric molecule comprising a human monoclonal antibody, or antigen binding fragment thereof, linked to an interferon,

• wherein the human monoclonal antibody or the antigen binding fragment thereof comprises a heavy chain variable domain and a light chain variable domain, and wherein:
• a) the heavy chain variable domain comprises amino acids 26-33 of SEQ ID NO:
• 1, amino acids 51-58 of SEQ ID NO:
• 1, and amino acids 97-103 of SEQ ID NO:
• 1;
• b) the light chain variable domain comprises amino acids 27-32 of SEQ ID NO:
• 2, amino acids 50-52 of SEQ ID NO:
• 2, and amino acids 89-97 of SEQ ID NO:
• 2;
• and
• c) the human monoclonal antibody or the antigen binding fragment thereof specifically binds human endoplasmin.