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US 11,078,258 B2Granted
Methods of treating and preventing Staphylococcus aureus infections and associated conditions
AssigneeNew York University
InventorsVictor J. Torres, Francis Alonzo, III
Life of this patent
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Abstract
The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
Claims8
A composition for immunizing a subject against S. aureus infection, said composition comprising:
- an isolated Leukocidin E (LukE) polypeptide, said polypeptide comprising an amino acid sequence of 50-200 amino acid residues of SEQ ID NO:
- 11;
- and
- a pharmaceutically acceptable carrier.
1 more element
A composition for immunizing a subject against S. aureus infection, said composition comprising:
- an isolated Leukocidin D (LukD) polypeptide, said polypeptide comprising an amino acid sequence of 50-200 amino acid residues of SEQ ID NO:
- 22;
- and
- a pharmaceutically acceptable carrier.
1 more element
Dependencies are inferred from the claim text.