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US 11,078,251 B2Granted
T cell receptors (TCR) and uses thereof for the diagnosis and treatment of diabetes
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite Paris Descartes, Centre National de la Recherche Scientifique (CNRS)
InventorsRoberto Mallone, Georgia Afonso, Ana Ines Lalanne, Slobodan Culina
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Abstract
The present invention relates to T-cell receptors (TCR) that recognize pancreatic betacell epitopes and uses thereof for the diagnosis and treatment of diabetes.
Claims1
A zinc transporter 8 (ZnT8)-specific T cell receptor (TCR) comprising an α chain and a β chain, wherein the CDR3 sequences of the β chain and the α chain comprise amino acid sequences as set forth in:
- SEQ ID NO:1 and SEQ ID NO:2 respectively, or
- SEQ ID NO:3 and SEQ ID NO:4 respectively, or
- SEQ ID NO:5 and SEQ ID NO:6 respectively, or
- SEQ ID NO:7 and SEQ ID NO:8 respectively, or
- SEQ ID NO:9 and SEQ ID NO:10 or SEQ ID NO:11 respectively, or
- SEQ ID NO:12 and SEQ ID NO:13 respectively, or
- SEQ ID NO:14 and SEQ ID NO:15 respectively, or
- SEQ ID NO:16 and SEQ ID NO:17 or SEQ ID NO:18 respectively, or
- SEQ ID NO:19 and SEQ ID NO:20 respectively, or
- SEQ ID NO:21 and SEQ ID NO:22 respectively, or
- SEQ ID NO:23 and SEQ ID NO:24 respectively.
8 more elements
Dependencies are inferred from the claim text.