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US 11,078,244 B2Granted
Composition and method for delivery of BMP-2 amplifler/co-activator for enhancement of osteogenesis
AssigneesFerring B.V., Brookhaven Science Associates, LLC
InventorsPaul Zamora, Brent Lee Atkinson, Xinhua Lin, Louis A. Pena
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Abstract
A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
Claims15
A method for preparing an implantable bone graft material comprising:
- forming an aqueous solution comprising a synthetic growth factor analogue having the structure
- wherein Hx is 6-aminohexanoic acid;
- and
- mixing the aqueous solution with an osteoconductive material, thereby binding a therapeutically effective amount of the synthetic growth factor analog to the osteoconductive material.
1 more element
A method for preparing an implantable bone graft material comprising:
- forming an aqueous solution comprising mannitol and a synthetic growth factor analogue having the structure
- wherein Hx is 6-aminohexanoic acid;
- and
- lyophilizing the solution to yield a lyophilized solid.
1 more element
Dependencies are inferred from the claim text.