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US 11,078,243 B2Granted
Cystine knot scaffold platform
AssigneeGenentech, Inc.
InventorsRami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
Life of this patent
Estimating the term…
Abstract
Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
Claims12
A peptide that comprises the amino acid sequence of any one of SEQ ID NOs:
- 102-112, 216-219, 221-223, 361-362, 365, 369-384, 405-413, 415, 417, 419-426, 428, 430-432, 436-446, 538-548, 555-566, and 568.
Dependencies are inferred from the claim text.