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US 11,078,238 B2Granted
AAVrh.10 variants with host antibody escape capabilities and altered tissue targeting properties
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsMavis Agbandje-McKenna, Mario Mietzsch
Life of this patent
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Abstract
This disclosure relates to variant AAVrh.10 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles.
Claims19
A recombinant adeno-associated virus rh.10 (rAAVrh.10) particle comprising a capsid protein comprising one or more mutations in positions selected from the group consisting of:
- Q589, N590, and A592 of SEQ ID NO:
- 2, wherein said mutations result in modulated reactivity to a neutralizing antibody and/or altered transduction efficiency relative to a wild-type AAVrh.10 particle having a capsid protein with an amino acid sequence of SEQ ID NO:
- 2.
A capsid protein of serotype AAVrh.10 comprising one or more mutations in positions selected from the group consisting of:
- Q589, N590, and A592 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.