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US 11,078,231 B2Granted
Process for purification of carfilzomib intermediate
AssigneeFresenius Kabi Oncology Limited
InventorsWalter Cabri, Saswata Lahiri, Govind Singh, Sarbjot Singh Sokhi, Maneesh Kumar Pandey, Raj Narayan Tiwari, Sonu Prasad Shukla
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Abstract
The present invention relates to a process for the purification of compound of formula II, wherein X may be independently selected from trifluoroacetic acid, hydrochloric acid, hydrobromic acid, p-toluene sulfonic acid and phosphoric acid; its isolation as solid and use for the preparation of carfilzomib.
Claims13
A process for purifying a compound of formula II,
- comprising an impurity of formula III:
- wherein X is independently trifluoroacetic acid, hydrochloric acid, hydrobromic acid, p-toluene sulfonic acid or phosphoric acid, the process comprising:
- a) treating the compound of formula II with an alkali metal perhalate in a solvent to reduce the amount of the impurity of Formula III in the compound of Formula II;
- b) adding an anti-solvent to precipitate the compound of formula II;
- and
- c) isolating a substantially pure compound of formula II.
3 more elements
Dependencies are inferred from the claim text.