High-purity large-scale preparation of stannsoporfin
AssigneeMallinckrodt Hospital Products IP Limited
InventorsGeorge S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
Life of this patent
Estimating the term…
Abstract
Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
Claims20
A composition comprising stannsoporfin, wherein the stannsoporfin is at least about 97% pure, and wherein any individual impurity is present in an amount less than about 0.08%, the stannsoporfin formed by:
- a) contacting a solution or suspension of tin (II) oxide with a mesoporphyrin IX or salt thereof under conditions suitable to form a crude stannsoporfin;
- and b) purifying the crude stannsoporfin to form the stannsoporfin.
A composition comprising stannsoporfin, wherein the stannsoporfin is at least about 97% pure, and wherein any individual impurity is present in an amount less than about 0.08%, the stannsoporfin formed by:
- a) exposing a metallic hydrogenation catalyst to a hydrogen atmosphere to form a pre-hydrogenated catalyst;
- b) contacting hemin with the pre-hydrogenated catalyst to form a mesoporphyrin IX or salt thereof;
- c) contacting a solution or suspension of tin (II) oxide with the mesoporphyrin IX or salt thereof under conditions suitable to form a crude stannsoporfin;
- and d) purifying the crude stannsoporfin via hot acid trituration, followed by treatment at high pH at or above pH 9 followed by re-acidification, and subsequent hot acid trituration to form the stannsoporfin.
Dependencies are inferred from the claim text.