US 11,078,213 B2 · Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof

Abstract

The present invention relates to thienopyrimidine compound, preparation method thereof, pharmaceutical composition and use thereof, and in particular to a type of compounds having ALK and/or c-Met selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with anaplastic lymphoma kinase in vivo, and in the manufacture of a medicament for preventing or treating a disease associated with angiogenesis or cancer metastasis, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Claims13

Dependent claims

A compound of Formula I

wherein:
R′ is H;
R1 is selected from the group consisting of:
A is a direct on or methylene;
X is NH, S or O;
R2 is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/324,040Filed 28 Sep 2017

Priority

CN 201610646949.89 Aug 2016

Published

US 2019/0211030 A111 Jul 2019

Granted

3 Aug 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 495/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61K 31/519
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with heterocyclic rings
A61K 31/5377
1,4-Oxazines, e.g. morpholine: not condensed and containing further heterocyclic rings, e.g. timolol
A61P 35/00
Antineoplastic agents

Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof

Life of this patent

Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof

Life of this patent

Abstract

Claims13