5-membered and bicyclic heterocyclic amides as inhibitors of rock

A compound of Formula (I):

• or a stereoisomer, an enantiomer, a diastereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:
• Ring A is selected from a 5-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S, and a bicyclic heteocycle;
• R1 is selected from H and C1-4 alkyl;
• R1a is C(O)R4;
• or R1 and R1a are taken together with the nitrogen atom to which they are attached to form a ring of Formula (Ia);
• R2 is selected from H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, —(CR10R10)nC3-10 carbocycle and —(CR10R10)n-4- to 15-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, alkenyl, alkynyl, carbocycle, and heterocycle are substituted with 1-4 R7;
• R3, at each occurrence, is independently selected from H, halogen, C1-6 alkyl, C2-6 alkenyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, —CH2OH, —OCH2F, —OCHF2, —OCF3, CN, —NH2, —NH(C1-4 alkyl), —N(C1-4 alkyl)2, —CO2H, —CH2CO2H, —CO2(C1-4 alkyl), —CO(C1-4 alkyl), —CH2NH2, —CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —OCH2CO2H, —NHCO(C1-4 alkyl), —NHCO2(C1-4 alkyl), —NHSO2(C1-4 alkyl), —SO2NH2, —C(═NH)NH2, a carbocycle, and a heterocycle, wherein said alkyl, alkenyl, alkoxy, alkylthio, haloalkyl, carbocycle, and heterocycle are substituted with 0-4 R9;
• R4 is selected from —(CR10R10)nC3-10 carbocycle and —(CR10R10)n-4- to 15-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p;
• wherein said carbocycle, and heterocycle are substituted with 1-4 R7;
• R5 is H;
• or R2 and R5 are taken together to form ═O;
• or R2 and R5 are taken together with the carbon atom, to which they are both attached, to form a carbocycle or heterocycle wherein said carbocycle and heterocycle are substituted with 1-4 R7;
• R6 is selected from H, C1-4 alkyl, —(CR10R10)nC3-10 carbocycle and —(CR10R10)n-4- to 15-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, alkenyl, carbocycle, and heterocycle are substituted with 1-4 R7;
• provided that R2, R5, and R6 are not all H;
• R7, at each occurrence, is independently selected from H, ═O, NO2, halogen, C1-7 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, CN, OH, CHF2, CF3, —(CH2)n—CO2H, —(CH2)n—CO2(C1-4 alkyl), —(CH2)n—NR8R8, —NHCOH, —NHCO(C1-4 alkyl), —NHCOCF3, —NHCO2(C1-4 alkyl), —NHCO2(CH2)2O(C1-4 alkyl), —NHCO2(CH2)3O(C1-4 alkyl), —NHCO2(CH2)2OH, —NHCO2(CH2)2NH2, —NHCO2(CH2)2N(C1-4 alkyl)2, —NHCO2CH2CO2H, —CH2NHCO2(C1-4 alkyl), —NHC(O)NR8R8, —NHSO2(C1-4 alkyl), —S(O)p(C1-4 alkyl), —SO2NH2, —SO2NH(C1-4 alkyl), —SO2N(C1-4 alkyl)2, —SO2NH(CH2)2OH, —SO2NH(CH2)2O(C1-4 alkyl), —(CH2)n—CONR8R8, —O(CH2)n-carbocycle, —O(CH2)n-heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH2)n-carbocycle, and —(CH2)n-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, alkenyl, alkynyl, alkoxy, carbocycle, and heterocycle are substituted with 0-4 R9;
• R8, at each occurrence, is independently selected from H, C1-6 alkyl, C2-4 alkenyl, C2-4 alkynyl, —(CH2)n—C(O)C1-4alkyl, —(CH2)n—C(O)carbocycle, —(CH2)n—C(O)heterocycle, —(CH2)n —C(O)NRaRa, —(CH2)n—NRaC(O) C1-4alkyl, —(CH2)n—C(O)OC1-4alkyl, —(CH2)n—C(O)C1-4alkyl, —(CH2)n—C(O)O-carbocycle, —(CH2)n—C(O)O-heterocycle, —(CH2)n—SO2alkyl, —(CH2)n SO2carbocycle, —(CH2)n—SO2heterocycle, —(CH2)n—SO2NRaRa, —(CH2)n-carbocycle, and —(CH2)n-heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R9;
• alternatively, R8 and R8 are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle substituted with 0-4 R9;
• R9, at each occurrence, is independently selected from halogen, OH, ═O, CN, NO2, C1-4 alkyl, C1-4 alkoxy, CO(C1-4 alkyl), CO2H, CO2(C1-4 alkyl), —(CHR10)nNRaRa, S(O)p(C1-4 alkyl), —(CHR10)nCONRaRa, —(CHR10)nNRaCO(C1-4 alkyl), —(CHR10)nOCONRa (CH2)nCO2Ra, S(O)pC1-4alkyl, S(O)pNRaRa, —O(CHR10)ncarbocycle, —O(CHR10)nheterocycle, —O(CHR10)nNRaRa, and —(CR10R10)n-4- to 10-membered heterocycle, wherein said alkyl, alkoxy, carbocycle, and heterocycle are substituted with 0-4 Rb;
• R10, at each occurrence, is independently selected from H and C1-4 alkyl;
• R11 is independently selected from H and C1-3 alkyl optionally substituted with halogen, C1-4 alkoxy, OH, CN, —CO2H, —CO2(C1-4 alkyl), —CO(C1-4 alkyl), —CONH2, —CONH(C1-4 alkyl), and —CON(C1-4 alkyl)2;
• R12 and R13 are independently selected from H, OH, —OC1-3 alkyl substituted with 0-4 Rd, C1-3 alkyl with substituted with 0-4 Rd;
• Ra, at each occurrence, is independently selected from H, C1-4 alkyl, —(CH2)nOH, CO(C1-4 alkyl), COCF3, CO2(C1-4 alkyl), —CONH2, —CONH—C1-4 alkylene-CO2(C1-4 alkyl), C1-4 alkylene-CO2(C1-4 alkyl), Rc, CO2Rc, and CONHRc;
• alternatively, Ra and Ra are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle, wherein said alkyl, alkylene, and heterocycle are substituted with 0-4 Rb;
• Rb, at each occurrence, is independently selected from ═O, OH, halogen, C1-4 alkyl, C1-4 alkoxy, OCF3, OC(O)C1-4 alkyl, NH2, NO2, N(C1-4 alkyl)2, CO(C1-4 alkyl), CO(C1-4 haloalkyl), CO2H, CO2(C1-4 alkyl), CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —CONH—C1-4 alkylene-O(C1-4 alkyl), —CONH—C1-4 alkylene-NH(C1-4 alkyl), —CONH—C1-4 alkylene-N(C1-4 alkyl)2, —C1-4 alkylene-O—P(O)(OH)2, —NHCO2(C1-4 alkyl), —Rc, CORc, CO2Rc, and CONHRc, wherein said alkyl and alkoxy are substituted with 0-2 Rd;
• Rc, at each occurrence, is independently selected from —(CH2)n—C3-6 cycloalkyl, —(CH2)n-phenyl, and —(CH2)-5- to 6-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of:
• N, NH, N(C1-4 alkyl), O, and S(O)p;
• wherein each ring moiety is substituted with 0-2 Rd;
• Rd, at each occurrence, is independently selected from ═O, halogen, OH, C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, C1-4 alkoxy, and —NHCO(C1-4 alkyl);
• n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4;
• and
• p, at each occurrence, is independently selected from 0, 1, and 2.