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US 11,078,194 B2Granted
Salt form and crystal form serving as FGFR and VEGFR inhibitor compounds, and preparation method therefor
AssigneeHarbin Zhenbao Pharmaceutical Co., Ltd.
InventorsZhengxia Chen, Yang Zhang, Meibi Dai, Hongfei Cheng, Suqin Yang, Wenju Li, Jian Li, Shuhui Chen
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Abstract
Disclosed in the present invention are a salt form and a crystal form serving as FGFR and VEGFR inhibitor compounds, a preparation method therefor, and medical uses thereof.
Claims10
A crystal form of a compound of formula (II), (III), or (IV):
- wherein the crystal form is a crystal form G of the compound of formula (II) or a crystal form I of the compound of formula (III) or a crystal form J of the compound of formula (IV), wherein:
- the X-ray powder diffraction pattern of the crystal form G of the compound of formula (II) comprises characteristic diffraction peaks at the following angle 2θ:
- 7.39±0.2°, 19.07±0.2°, and 20.04±0.2°;
- the X-ray powder diffraction pattern of the crystal form I of the compound of formula (III) comprises characteristic diffraction peaks at the following angle 2θ:
- 6.73±0.2°, 11.66±0.2°, and 19.51±0.2°;
- and the X-ray powder diffraction pattern of the crystal form J of the compound of formula (IV) comprises characteristic diffraction peaks at the following angle 2θ:
- 4.99±0.2°, 11.32±0.2°, and 19.95±0.2°.
4 more elements
Dependencies are inferred from the claim text.