1-(4-amino-5-bromo-6-(1H-pyrazol-1-yl)pyrimidin-2-yl)-1H-pyrazol-4-ol and use thereof in the treatment of cancer

The compound 1-(4-amino-5-bromo-6-(1H-pyrazol-1-yl)-pyrimidin-2-yl)-1H-pyrazol-4-ol, in an isolated form.

A pharmaceutical composition comprising, 1-(4-amino-5-bromo-6-(1H-pyrazol-1-yl)-pyrimidin-2-yl)-1H-pyrazol-4-ol, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient for simultaneous, concurrent, or sequential use.

A combination, comprising a therapeutically effective amount of 1-(4-amino-5-bromo-6-(1H-pyrazol-1-yl)-pyrimidin-2-yl)-1H-pyrazol-4-ol, or a pharmaceutically acceptable salt thereof and one or more immunotherapeutic agents.

A method of treating cancer, in a subject in need of such treatment, the method comprising:

• administering to a subject in need thereof, a therapeutically effective amount of 1-(4-amino-5-bromo-6-(1H-pyrazol-1-yl)-pyrimidin-2-yl)-1H-pyrazol-4-ol , or a pharmaceutically acceptable salt thereof;
• alone or in combination with one or more immunotherapeutic agents wherein the cancer is selected from a lung cancer, a melanoma, a renal cancer, a liver cancer, a myeloma, a prostate cancer, a breast cancer, a colorectal cancer, a pancreatic cancer, a head and neck cancer, anal cancer, gastro-esophageal cancer, thyroid cancer, cervical cancer, a lymphoproliferative disease or a hematological cancer, T-cell lymphoma, B-cell lymphoma, a non-Hogdkin lymphoma, or a leukemia.

The method, according to embodiment 10, wherein the anti-PD-1 antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:

• 8 and a light chain comprising the amino acid sequence of SEQ ID NO:
• 22.

The method, according to embodiment 10, wherein the anti-PD-1 antibody comprises a VH comprising the amino acid sequence of SEQ ID NO:

• 6 and a VL comprising the amino acid sequence of SEQ ID NO:
• 16.

The method, according to embodiment 10, wherein the anti-PD-1 antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:

• 8 and a light chain comprising the amino acid sequence of SEQ ID NO:
• 18.