Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof

A compound of the formula (I), or a stereoisomer, prodrug, solvate, hydrate, crystal form or pharmaceutically acceptable salt thereof:

• wherein,
• R1, R2 and R3 are each independently hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted 3-8-membered heterocyclyl, substituted or unsubstituted —C(═O)Rx or substituted or unsubstituted benzyl;
• wherein Rx is C1-C6 alkyl, C1-C6 alkoxy or C3-C10 cycloalkyl;
• the wavy line indicates that the configuration is R type, S type or racemate;
• A ring is 5-10 membered heteroaryl, 5-8 membered heterocyclyl, or C6-C10 aryl;
• X is C or N;
• R4 is substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted benzyl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl;
• R5 is absent, hydrogen, substituted or unsubstituted C1-C6 alkyl,
• wherein R6 and R7 are each independently hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted benzyl, substituted or unsubstituted 5-10 membered heterocyclyl or substituted or unsubstituted 5-10 membered heteroaryl;
• or R6 and R7 together with the nitrogen atom to which they are attached form substituted or unsubstituted 5-15 membered heterocyclyl;
• the substitution means that there is one or more substituents selected from the group consisting of halogen, hydroxy, nitro, cyano, tert-butoxycarbonyl, C1-C6 alkyl, C1-C6 alkoxy, C3-C10 cycloalkyl and NR8R9;
• R8 and R9 are each independently hydrogen, C1-C6 alkyl, C3-C10 cycloalkyl, benzyloxycarbonyl (Cbz), tert-butoxycarbonyl (Boc), fluorenylmethoxycarbonyl (Fmoc), methoxycarbonyl, ethoxycarbonyl, phthaloyl (Pht), p-toluenesulfonyl (Tos), trifluoroacetyl (Tfa), pivaloyl, benzoyl, trityl (Trt), 2,4-dimethoxybenzyl (Dmb), p-methoxybenzyl (PMB) or benzyl (Bn).