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US 11,078,166 B2Granted
Triazole conjugated ureas, thioureas, carbamates, and reversed carbamates for PSMA-targeted imaging agents and uses thereof
AssigneeThe Johns Hopkins University
InventorsMartin G. Pomper, Ying Chen, Xing Yang, Ronnie C. Mease, Sangeeta Ray
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Abstract
Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.
Claims1
A compound having the following structure:
Dependencies are inferred from the claim text.