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US 11,078,158 B2Granted
(+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine or pharmaceutically acceptable salts thereof, a process for preparation thereof and uses thereof
AssigneeIntegrative Research Laboratories Sweden AB
InventorsClas Sonesson, Maija Buksa, Inese Reine
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Abstract
The disclosure provides a process for manufacturing thereof a salt of Formula IIb:
Claims14
A process for manufacturing the salt of Formula IIb
- said process comprising:
- resolution of a compound of Formula I:
- by combining said compound of Formula I with (−)-dibenzoyl-L-tartaric acid in the presence of at least one solvent thereby providing a salt of Formula IIa:
- optionally isolating and drying the salt of Formula IIa,
- removing the (−)-dibenzoyl-L-tartaric acid from the salt of Formula IIa thereby providing a compound of Formula II,
- and
- combining the compound of Formula II with fumaric acid thereby providing the salt of Formula IIb.
4 more elements
A salt of Formula IIa:
Dependencies are inferred from the claim text.