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US 11,077,475 B2Granted
Neuro-chemical sensor with inhibition of fouling on nano-electrode
AssigneeInternational Business Machines Corporation
InventorsSteven J. Holmes, Emily R. Kinser, Qinghuang Lin, Nathan P. Marchack, Roy R. Yu
Life of this patent
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Abstract
A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.
Claims9
A device, comprising:
- an array of metal nanorods formed on a substrate, wherein each of the metal nanorods in the array are separated from adjacent metal nanorods by a distance;
- an encapsulation wall surrounding at least a subset of the array of nanorods and separated from adjacent metal nanorods by a distance;
- an electropolymerized conductor formed over tops of the subset of the array of nanorods and the encapsulation wall to form an enclosed reservoir between the electropolymerized conductor, the encapsulation wall, and the substrate, wherein the electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods;
- a dispensing material loaded in the reservoir to be dispersed in accordance with open pores;
- and
- a control circuit that controls the electrical signals applied to the nanorods and an electric field, wherein the electric field is configured to retard cell growth using a pulsed signal sufficient to induce apoptosis in cells.
3 more elements
A device, comprising:
- an array of metal nanorods formed on a substrate, the array of metal nanorods being grouped into a first region and a second region, the nanorods in the first region having a first spacing therebetween different than a second spacing of nanorods in the second region;
- and
- a controller circuit configured to direct voltage to a selected one of the first region and second region, wherein:
- voltage directed by the controller circuit to activate the first region generates an electric field that retards cell growth, wherein the electric field includes a nanosecond pulsed signal sufficient to induce apoptosis in cells;
- and
- voltage directed by the controller circuit to activate the second region generates an electric field that stimulates cell growth.
3 more elements
Dependencies are inferred from the claim text.