3-dimensional large capacity cell encapsulation device assembly
AssigneeViaCyte, Inc.
InventorsVincent So, Laura Martinson, Chad Green, Michael Scott, Mario Zamarripa
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Abstract
Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes.
Claims21
A foldable cell encapsulating assembly, said assembly comprising at least two planar cell chambers and a cell-free region along the longest axis separating the at least two planar cell chambers, wherein each chamber comprises a semi-permeable membrane and the first chamber is completely sealed from the second chamber, and wherein the cell-free region comprises a bendable region interconnecting the at least two planar cell chambers, wherein the semi-permeable membrane of each chamber has an inner surface configured to be in contact with cells that are placed in the respective chamber, wherein each chamber is configured to be sealed to contain the cells that are placed in the respective chamber, and wherein at least a portion of an outer surface of the cell encapsulating assembly is configured to be placed in direct contact with host tissue upon implantation of the cell encapsulating assembly into a mammalian host, wherein the assembly is shape set to have a corrugated configuration in which the at least two planar cell chambers are spaced apart from each other by the bendable region.
A foldable cell encapsulating assembly, said assembly comprising at least two planar cell chambers and a cell-free region along the longest axis separating the at least two planar cell chambers, wherein each chamber comprises a semi-permeable membrane and the first chamber is completely sealed from the second chamber, and wherein the cell-free region comprises a bendable region interconnecting the at least two planar cell chambers, wherein each chamber includes a volume of cells and is sealed to contain the volume of cells in the respective chamber, wherein the semi-permeable membrane of each chamber has an inner surface in contact with the cells in the respective chamber, and wherein at least a portion of an outer surface of the cell encapsulating assembly is configured to be placed in direct contact with host tissue upon implantation of the cell encapsulating assembly into a mammalian host, wherein the assembly is shape set to have a corrugated configuration in which the at least two planar cell chambers are spaced apart from each other by the bendable region, and wherein the semi-permeable membrane is perforated.
A foldable cell encapsulating assembly, said assembly comprising at least two planar cell chambers and a cell-free region along the longest axis separating the at least two planar cell chambers, wherein each chamber comprises a semi-permeable membrane and the first chamber is completely sealed from the second chamber, and wherein the cell-free region comprises a bendable region interconnecting the at least two planar cell chambers, wherein the semi-permeable membrane of each chamber has an inner surface configured to be in contact with cells that are placed in the respective chamber, wherein each chamber comprises at least one loading port configured to be sealed to contain the cells that are placed in the respective chamber, and wherein at least a portion of an outer surface of the cell encapsulating assembly is configured to be placed in direct contact with host tissue upon implantation of the cell encapsulating assembly into a mammalian host, wherein the assembly is shape set to have a corrugated configuration in which the at least two planar cell chambers are spaced apart from each other by the bendable region.
Dependencies are inferred from the claim text.