US 11,077,234 B2 · Antimicrobial coatings for medical implements and medical devices

Abstract

The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Claims15

Dependent claims

A method of coating an implantable medical device, the method comprising:

immersing the implantable medical device in an aqueous composition comprising octadecyldimethyl-(3-trimethoxysilylpropyl) ammonium chloride, 3-chloropropyltrimethoxysilane, triethanolamine and water;
drying the implantable medical device under ambient conditions to produce a coating on the implantable medical device;
and
curing the coating on the implantable medical device by heating the implantable medical device at between about 100° C. to about 1000° C. to produce a cured coating on the implantable medical device;
wherein the aqueous composition is of the formulation:
0.75 wt. % octadecyldimethyl-( 3-trimethoxysilylpropyl) ammonium chloride, 0.12 wt. % 3-chloropropyltrimethoxysilane, 0.045 wt. % triethanolamine, and 99.085 wt. % water;
and
wherein the cured coating on the implantable medical device exhibits a residual antimicrobial efficacy against at least one of S. epidermidis or E. aerogenes.

5 more elements

Dependencies are inferred from the claim text.

Antimicrobial coatings for medical implements and medical devices

Life of this patent

Antimicrobial coatings for medical implements and medical devices

Life of this patent

Abstract

Claims15