US 11,077,227 B2Granted

Ultrahigh ductility, novel Mg—Li based alloys for biomedical applications

AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education

InventorsPrashant N. Kumta, Jingyao Wu, Oleg Velikokhatnyi

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Abstract

The invention relates to compositions including magnesium-lithium alloys containing various alloying elements suitable for medical implant devices. The devices may be constructed of the compositions or have applied thereto a coating formed therefrom. Within the structure of the magnesium-lithium alloy, there is a co-existence of alpha and beta phases. The invention also relates to methods of preparing the magnesium-lithium alloys and articles, such as medical implant devices, for use in medical applications, such as but not limited to, orthopedic, dental, craniofacial and cardiovascular surgery.

Claims8

Dependent claims

A biodegradable medical implant device composed of a ductile, dual phase magnesium-based alloy, consisting of:

the dual phase-magnesium-based alloy having co-existing alpha and beta phases, selected from the group consisting of:
(i) 9.00% by weight lithium based on total weight of the alloy;
0.96% by weight zinc based on total weight of the alloy;
0.01% by weight aluminum based on total weight of the alloy;
and
a remainder of magnesium, or
(ii) 8.99% by weight lithium based on total weight of the alloy;
0.87% by weight zinc based on total weight of the alloy;
1.07% by weight aluminum based on total weight of the alloy;
and
a remainder of magnesium, or
(iii) 6.11% by weight lithium based on total weight of the alloy;
0.92% by weight zinc based on total weight of the alloy;
0.04% by weight aluminum based on total weight of the alloy;
and
a remainder of magnesium;
and
optionally, an active agent,
wherein each of the alloys (i), (ii) and (iii) exhibits an elongation of about 48%, about 50% and about 45%, respectively.

16 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/532,149Filed 9 Dec 2015 · us provisional application
Priority: 12 Dec 2014
Published: US 2017/0266346 A121 Sep 2017
Granted: 3 Aug 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61L 27/30
Materials for coating prostheses: inorganic materials
A61L 27/047
Metals or alloys: other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
A61L 27/306
Inorganic materials: other specific inorganic materials not covered by A61L27/303 - A61L27/32
A61L 27/54
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…

Family

Application62/090,939Us provisional application · filed 12 Dec 2014
US 2017/0266346 A1Pre-grant publication · published 21 Sep 2017
US 11,077,227 B2This patent

From the US filing history. Foreign family members aren’t listed.

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