Hollow porous spherical particle artificial bone as well as preparation method and application thereof

A preparation method of a hollow porous spherical particle artificial bone, comprising the following steps:

• (1) uniformly mixing bioceramic powder, bioglass powder and an excipient to obtain a solid-phase mixture, then adding binder solution to the solid-phase mixture and uniformly mixing to obtain a plastic wet material;
• wherein, in the solid-phase mixture, the mass fraction of the excipient is 10%-85%;
• the mass ratio of bioceramic to a glass sintering additive is 0.01-100;
• the mass ratio of the binder to solid-phase mixture is 0.2-3;
• (2) loading the plastic wet material obtained in step (1) into an extrusion device of an extrusion rounder to be extruded by an orifice plate of the extrusion device to form a strip-shaped material;
• (3) putting the strip-shaped material obtained in step (2) into an spheronization device, cutting, and then spheronizing to form spherical particles;
• and
• (4) placing the spherical particles obtained in step (3) into a furnace, debinding, removing the excipient and the binder, and then sintering at 750-1550° C. to obtain a hollow porous spherical particle artificial bone,
• wherein the artificial bone is of a hollow spherical shell structure, and macropores and micropores are distributed on the spherical shell.