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US 11,077,211 B2Granted
Compositions and methods for assessing gut function
AssigneeMediBeacon Inc.
InventorsRichard B Dorshow, Steven J. Hanley, Phillip I. Tarr
Life of this patent
Estimating the term…
Abstract
Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.
Claims14
A method for assessing gut function in a human subject in need thereof, the method comprising the steps of:
- a. orally administering to the subject an effective amount of a composition comprising two fluorescent challenge molecules, wherein the first fluorescent challenge molecule is not substantially absorbed by a healthy gut, and wherein the second fluorescent challenge molecule is substantially absorbed by a healthy gut into the subject's gut;
- b. irradiating the composition absorbed by the subject's gut with non-ionizing radiation, wherein the radiation causes the composition to fluoresce;
- c. detecting the fluorescence of the fluorescent challenge molecules in the composition;
- and
- d. assessing gut function in the subject based on the detected fluorescence,
- wherein the first fluorescent challenge molecule is selected from the group consisting of 3,6-diamino-2,5-bis {N-[(1R)-1-carboxy-2-hydroxyethyl]carbamoyl}pyrazine and 3,6-N,N′-bis(2,3-dihydroxypropyl)-2,5-pyrazinedicarboxamide, and
- wherein the second fluorescent challenge molecule is selected from the group consisting of acridines, acridones, anthracenes, anthracylines, anthraquinones, azaazulenes, azo azulenes, benzenes, benzimidazoles, benzofurans, benzoindocarbocyanines, benzoindoles, benzothiophenes, carbazoles, coumarins, cyanines, dibenzofurans, dibenzothiophenes, dipyrrolo dyes, flavones, fluoresceins, imidazoles, indocarbocyanines, indocyanines, indoles, isoindoles, isoquinolines, naphthacenediones, naphthalenes, naphthoquinones, phenanthrenes, phenanthridines, phenanthridines, phenoselenazines, phenothiazines, phenoxazines, phenylxanthenes, polyfluorobenzenes, purines, pyrazines, pyrazoles, pyridines, pyrimidones, pyrroles, quinolines, quinolones, rhodamines, squaraines, tetracenes, thiophenes, triphenyl methane dyes, xanthenes, xanthones, and derivatives thereof, and
- wherein the non-ionizing radiation has a wavelength of at least 350 nm.
5 more elements
A method of assessing the location of a disease or an injury in a human subject's gut, the method comprising the steps of:
- a. orally administering to the subject an effective amount of a composition comprising two fluorescent challenge molecules, wherein the first fluorescent challenge molecule is not substantially absorbed by a healthy gut, and wherein the second fluorescent challenge molecule is substantially absorbed by a healthy gut into the subject's gut;
- b. irradiating the composition absorbed by the subject's gut with non-ionizing radiation, wherein the radiation causes the composition to fluoresce;
- c. detecting the fluorescence of the fluorescent challenge molecules in the composition;
- and
- d. assessing the location of disease or injury in the subject's gut, based on the time between the detected fluorescence of each fluorescent challenge molecule and administration,
- wherein the first fluorescent challenge molecule is selected from the group consisting of 3,6-diamino-2,5-bis {N-[(1R)-1-carboxy-2-hydroxyethyl]carbamoyl}pyrazine and 3,6-N,N′-bis(2,3-dihydroxypropyl)-2,5-pyrazinedicarboxamide, and
- wherein the second fluorescent challenge molecule is selected from the group consisting of acridines, acridones, anthracenes, anthracylines, anthraquinones, azaazulenes, azo azulenes, benzenes, benzimidazoles, benzofurans, benzoindocarbocyanines, benzoindoles, benzothiophenes, carbazoles, coumarins, cyanines, dibenzofurans, dibenzothiophenes, dipyrrolo dyes, flavones, fluoresceins, imidazoles, indocarbocyanines, indocyanines, indoles, isoindoles, isoquinolines, naphthacenediones, naphthalenes, naphthoquinones, phenanthrenes, phenanthridines, phenanthridines, phenoselenazines, phenothiazines, phenoxazines, phenylxanthenes, polyfluorobenzenes, purines, pyrazines, pyrazoles, pyridines, pyrimidones, pyrroles, quinolines, quinolones, rhodamines, squaraines, tetracenes, thiophenes, triphenyl methane dyes, xanthenes, xanthones, and derivatives thereof, and
- wherein the non-ionizing radiation has a wavelength of at least 350 nm.
5 more elements
Dependencies are inferred from the claim text.