Synthetic compound for improving efficiency of transfection

A synthetic compound for enabling transfection of eukaryotic cells, in combination with an amphiphilic block copolymer which synthetic compound comprises a peptide residue having at least one targeting sequence and a nucleic acid binding sequence which nucleic acid binding sequence comprises at least four consecutive amino acid residues which are positively charged at pH 7.4, wherein the peptide residue comprises SEQ ID Nos:

• SEQ ID NO:
• 1, SEQ ID NO:
• 2, SEQ ID NO:
• 4, SEQ ID NO:
• 5, SEQ ILS NO:
• 6, SEQ ID NO:
• 7, SEQ ID NO:
• 8, SEQ ID NO:
• 9 or SEQ ID NO:
• 10, wherein the synthetic compound further comprises a hydrophobic moiety covalently linked to the peptide residue, wherein the hydrophobic moiety comprises lipoic acid residue, lipoamide residue, a tetradecyl residue, a cholesteryl residue, or a further peptide residue having a sequence with more than 40% amino acid residues with hydrophobic side chains, the further peptide comprising at least four amino acid residues with hydrophobic side chains, wherein the amino acid residues with hydrophobic side chains are amino acid residues of phenylalanine, tyrosine and tryptophan and the targeting sequence comprises a nuclear localization signal (NLS) sequence, a skeletal muscle cell ligand, a myocardium ligand, and/or an epithelium ligand sequence.