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US 11,077,199 B2Granted
Albumin binding peptide conjugates and methods thereof
AssigneeMassachusetts Institute of Technology
InventorsKelly Dare Moynihan, Rebecca Lynn Holden, Darrell J. Irvine, Bradley Lether Pentelute
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Abstract
The present invention provides a conjugate comprising an albumin binding peptide and a cargo, compositions for directing cargos to the lymphatic system, and vaccines. The methods of the invention can be used to increase an immune response, or to treat cancer or an infectious disease.
Claims24
A conjugate for priming an endogenous immune response comprising:
- (a) an albumin binding peptide;
- and
- (b) an immunomodulatory molecule, wherein the immunomodulatory molecule is a peptide antigen or an immunostimulatory oligonucleotide,
- and wherein the albumin binding peptide is operatively coupled to the immunomodulatory molecule with or without a linker domain, thereby providing a conjugate for priming an endogenous immune response.
1 more element
A composition for directing immunomodulatory molecules to the lymphatic system, wherein the composition comprises a conjugate comprising:
- (a) an albumin binding peptide;
- and
- (b) an immunomodulatory molecule,
- wherein the immunomodulatory molecule is a peptide antigen or an immunostimulatory oligonucleotide, and wherein the albumin binding peptide is operatively coupled to the immunomodulatory molecule with or without a linker domain.
1 more element
Dependencies are inferred from the claim text.