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US 11,077,198 B2Granted
Pegylated carfilzomib compounds
AssigneeAmgen Inc.
InventorsGary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
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Abstract
The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
Claims25
A process of making a compound having the structure
- the process comprising the step of
- wherein X— is a counter ion salt selected from the group consisting of a chloride anion, a bisulfate anion, a sulfate anion, a nitrate anion, a phosphate anion, an alky-sulfonate anion or an aryl-sulfonate anion;
- R1 is C1-10alkyl or C3-7cycloalkyl;
- and PEG is a polyethylene glycol polymeric moiety having a molecular weight ranging from about 500 to about 20K.
1 more element
Dependencies are inferred from the claim text.