Methods for photodynamic therapy
AssigneeDUSA Pharmaceuticals, Inc.
InventorsScott Lundahl, Michael Guttadauro
Life of this patent
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Abstract
A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
Claims14
A method of photodynamic treatment of actinic keratosis, comprising:
- applying 5-aminolevulinic acid (ALA) in gel form to an actinic keratotic lesion on the stratum corneum of an upper extremity;
- and
- reducing evaporation from a portion of the stratum corneum including an area where the lesion is present using an occlusive dressing,
- wherein reducing evaporation comprises applying the occlusive dressing to the area and keeping the occlusive dressing on the area at a temperature between about 19° C. to about 22° C.
A method of photodynamic treatment of actinic keratosis, comprising:
- applying 5-aminolevulinic acid (ALA) in gel form to an actinic keratotic lesion on the stratum corneum of an upper extremity;
- and
- reducing evaporation from a portion of the stratum corneum including an area where the lesion is present using an occlusive dressing,
- wherein reducing evaporation further comprises keeping the occlusive dressing on the area at a temperature between about 19° C. to about 22° C.
A method of photodynamic treatment of actinic keratosis, comprising:
- applying a topical composition of 5-aminolevulinic acid (ALA) hydrochloride at a concentration of 20% by weight to an actinic keratotic lesion on the stratum corneum of an upper extremity;
- and
- reducing evaporation from a portion of the stratum corneum including an area where the lesion is present using an occlusive dressing,
- wherein reducing evaporation comprises applying the occlusive dressing to the area and keeping the occlusive dressing on the area at a temperature between about 19° C. to about 22° C.
Dependencies are inferred from the claim text.