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US 11,077,191 B2Granted
Multimodal therapy for cancer cell destruction
AssigneeSoutheast Missouri State University
InventorsSantaneel Ghosh, Somesree GhoshMitra
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Abstract
The field of the disclosure relates generally to cancer cell destruction and, more specifically, to cancer cell destruction by photo-magnetic irradiation mediated multimodal therapy using smart nanostructures.
Claims11
A nanostructure for cancer cell destruction, the nanostructure comprising:
- a cluster of nanoparticles comprising:
- at least one core-shell magnetic nanosphere (CSMNS) nanoparticle, at least one capped gold nanoparticle (AuNP), and at least one a cisplatin loaded thermo-responsive polymeric nanoparticle (CPNP), wherein the cisplatin is loaded inside the CPNP.
A multimodal method of cancer cell destruction, the method comprising:
- applying optical irradiation induced temperature change to at least one nanostructure comprising a cluster of nanoparticles;
- simultaneously applying an oscillating magnetic field to the at least one nanostructure, wherein the cluster of nanoparticles comprises at least one core-shell magnetic nanosphere (CSMNS) nanoparticle, at least one capped gold nanoparticle (AuNP), and at least one thermo-responsive polymeric nanoparticle comprising cisplatin (CPNP), and wherein the simultaneous optical irradiation induced temperature change and oscillating magnetic field application creates a sustained release of the cisplatin from the CPNP;
- and,
- interacting the released cisplatin with at least one cancer cell to destroy the cell.
1 more element
Dependencies are inferred from the claim text.