Nanoparticle delivery system for targeted anti-obesity treatment
AssigneeUniversity of Wyoming
InventorsBaskaran Thyagarajan, Padmamalini Baskaran
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Abstract
A magnetic nanoparticle including a TRPV1 agonist, as well as methods of preparation and use, are described herein. A magnetically responsive pharmaceutical can include a core region having a magnetic nanoparticle (MNPs) and a TRPV1 protein agonist. Further, an exterior coating comprising a polymer can be formed around the core region. The magnetically responsive pharmaceutical can be administered to a recipient and directed to a target region using an external magnetic field.
Claims20
A method for making a magnetically responsive pharmaceutical, comprising:
- precipitating ferromagnetic metal salts in the presence of ammonium hydroxide to obtain magnetic nanoparticles (MNPs);
- depositing a TRPV1 protein agonist around the MNPs;
- and
- coating the MNPs and the TRPV1 protein agonist with a biodegradable polymer.
A method for making a magnetically responsive pharmaceutical, comprising:
- precipitating ferromagnetic metal salts in the presence of ammonium hydroxide to obtain magnetic nanoparticles (MNPs);
- magnetically filtering and washing the MNPs;
- depositing a TRPV1 protein agonist around the MNPs to form an intermediate layer over the MNPs;
- and
- depositing a biodegradable polymer over the intermediate layer.
Dependencies are inferred from the claim text.