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AssigneeOklahoma Medical Research Foundation
InventorsXiao-Yan Zhao, Andreas Wilmen, Christoph Freiberg, Lars Linden, Ji-Yun Kim, Subramanian Yegneswaran, Karin Regnstrom, Ursula Egner, Xinquan Wang
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Provided are optimized humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. In particular, the antibodies bind to particular epitopes outside the catalytic triad of the active site of human activated protein C. Methods of treatment employing these antibodies are described herein.
A human or humanized monoclonal antibody or human or humanized antibody fragment that is capable of specifically binding activated human protein C, but not unactivated human protein C, wherein said antibody or antibody fragment comprise a variable light chain of SEQ ID NO:
A method of treating a subject in need of coagulation comprising administering to said subject an human or humanized antibody or human or humanized antibody fragment that is capable of specifically binding activated human protein C, but not unactivated human protein C, wherein said antibody or antibody fragment comprise a variable light chain of SEQ ID NO:
Dependencies are inferred from the claim text.