Vaccine to pathogenic immune activation cells during infections
Assignee21C Bio
InventorDaniel Zagury
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Abstract
In the present invention, the Applicant provides a novel method for preventing or treating an infectious disease in a subject in need thereof. In particular said method comprise the administration of a combination, pharmaceutical combination, medicament or kit-of-parts comprising a first part comprising a CD8 vaccine specific for at least one infectious disease-related antigen, optionally a second part comprising an interferon alpha blocking agent, and a third part comprising a type III interferon and/or an agent stimulating the production of type III interferon.
Claims18
A method for prophylactically treating acquired immune deficiency syndrome (AIDS) in a subject in need thereof, comprising administering to the subject:
- 1) a CD8 therapeutic vaccine specific for at least one human immunodeficiency virus (HIV) antigen,
- 2) optionally interferon-alpha blocking agent, and
- 3) a type III interferon and/or an agent stimulating the production of type III interferon, wherein the type III interferon comprises at least one IFN-λ selected from the group consisting of IFN-λ1, IFN-λ2 IFN-λ3 and IFN-λ4, and wherein the agent stimulating the production of type III interferon comprises at least one TLR ligand, RIG-I ligand, and/or MDA5 ligand.
Dependencies are inferred from the claim text.